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Virtual CME Program
1.00 CME/CE Credit
Heart Failure with Preserved Ejection Fraction: A Misunderstood Disease in Search of a Therapy
Heart failure with preserved ejection fraction (HFpEF) has long been considered one of the most challenging forms of heart failure to diagnose and treat. With evolving diagnostic frameworks and recent landmark clinical trials, the therapeutic landscape has changed dramatically.
This session reviews practical approaches to diagnosing HFpEF and highlights the latest evidence supporting SGLT2 inhibitors, ARNI therapy, and nonsteroidal MRAs. Clinicians will gain clarity on treatment selection across the ejection fraction spectrum and leave equipped to apply contemporary, guideline-informed strategies to improve outcomes in patients with mildly reduced or preserved ejection fraction.
CME/CE Information
1.00 AMA PRA Category 1 Credits, 1.00 ABIM MOC or 1.00 AANP, including 0.33 AANP Pharm
Release Date: 3/4/2026
Expiration Date: 6/2/2026
Topics
Faculty
Learning Objectives
- Identify patients at risk for HFpEF, and apply a practical outpatient diagnostic approach, including appropriate use of natriuretic peptides and echocardiography
- Differentiate HFpEF from other common causes of dyspnea and edema in patients with multimorbidity
- Initiate and optimize evidence-based therapy for HFpEF and HFmrEF, including appropriate use of SGLT2 inhibitors and coordination of specialty referral when indicated
Faculty
Scott D. Solomon, MD
The Edward D. Frohlich Distinguished Chair, Professor of Medicine, Harvard Medical School, Boston, MA
Director, Noninvasive Cardiology, Senior Physician, Brigham and Women's Hospital, Boston, Massachusetts
International Associate Editor, European Heart Journal, Boston, Massachusetts
Learn MoreDisclosures
The following relevant financial relationships have been disclosed by those in a position to influence the content of this activity. All have been mitigated by Pri-Med Institute:
Scott D. Solomon, MD: Advisor and Consultant for Amgen; Consultant for AstraZeneca; Consultant and Researcher for Bayer, Bristol Myers Squibb, Boston Scientific, Cytokinetics; Researcher for Alexion, Alnylam, Applied Therapeutics, Edgewise, Gossamer, Ionis, Respicardia; Consultant for Lexicon.
Peter Libby, MD (Moderator):
Advisor and Consultant for Amgen, Kowa Pharmaceuticals; Consultant for AstraZeneca, Esperion Therapeutics, Merck, Novartis, Pfizer, Sanofi-Regeneron; Consultant and Researcher for Novo Nordisk; Consultant and Researcher for Genentech; Stock Holder for iRhythm Technologies.
All others in control of content for this activity have disclosed no relevant financial relationships.
CME/CE Information
AMA PRA Category 1 Credits
Accreditation Statement
Pri-Med Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Designation Statement
Pri-Med Institute designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
AANP
Accreditation Statement
Pri-Med Institute is accredited by the American Association of Nurse Practitioners® as an approved provider of nurse practitioner continuing education. Provider number: 040308.
Designation Statement
This activity is approved for 1.00 contact hour of continuing education, which includes 0.33 hours of pharmacology.
MOC Credit Information
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge MOC point in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Instructions for Obtaining Credit
Fine Print
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The opinions, ideas, and recommendations expressed in this educational activity are those of the faculty only and are not necessarily endorsed by, nor do they necessarily reflect, those of their affiliated institutions, Pri-Med Institute, Pri-Med Institute Advisory Boards and Consultants, DBC Pri-Med, LLC.
Clinical judgment must guide each clinician in weighing the possible risks, benefits, or contraindications of any diagnostics, interventions or treatments discussed. Clinicians should review manufacturers’ product information and consider these with the recommendations of other authorities when applying the assessment and/or clinical management strategies discussed in this activity to the care of their patients.
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Disclosures and Conflict of Interest
Pri-Med Institute requires all individuals in a position to influence educational content for Pri-Med Institute-certified CME/CE activities to disclose personal financial relationships with commercial interests or ineligible companies prior to contributing to its educational activities. Pri-Med Institute assesses disclosed relationships and follows a defined process to mitigate real or implied conflicts to ensure, to the best of its ability, that all educational content is free of commercial bias. All relevant financial relationships have been mitigated Financial disclosures for everyone in control of educational content are provided before the start of each CME/CE activity.
Discussion of Off-Label Uses and Investigational Products
During the course of their presentations, the faculty may mention uses of products that have not been approved in the United States for the indication(s) being discussed. All presenters are instructed to notify participants when they are discussing unapproved uses or investigational agents. In addition, specific slides will include notation of the off-label use or investigational agent being discussed. Views presented related to unapproved uses of products are solely those of the presenter(s) and are not endorsed by Pri-Med Institute or DBC Pri-Med, LLC.
Questions?
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